Alice-Georgiana Stoica
ACS - Centrul de Bioanaliză
Biografie
Am absolvit Facultatea de Biologie, departamentul de Biochimie, în cadrul Universității din București, în anul 2021, prezentând o lucrare de licență axată pe similaritățile dintre bariera intestinală și cea hematoencefalică, interacțiunea dintre acestea, precum și importanța disbiozei în dezvoltarea bolilor neuroinflamatorii și neurodegenerative.
În căutarea unei evoluții profesionale continue, am urmat apoi un Master în Genetică Aplicată și Biotehnologie, tot în cadrul Universității București, pe care l-am finalizat în 2023. Lucrarea de masterat a fost dedicată analizei genotoxicității nanoparticulelor de Ag și ZnO utilizate în fabricarea biomaterialelor ustensilelor medicale cu scopul de a reduce infecțiile nosocomiale, un domeniu de cercetare deosebit de relevant și actual.
Pe parcusul anilor de studiu si a stagiilor de practica la diferite institute si laboratoare am deprins competențe in utilizarea a numeroase tehnici și metode printre care electroforeză, PCR, Western blot, cromatografie, microscopie și culturi celulare.
Publicatii
| Publication | Authors | Date | |
|---|---|---|---|
article
N-Doped Nanocrystalline Graphite Electrochemical Sensor For Oleuropein Detection From Extra Virgin Olive Oils |
Albu Camelia; Chira Ana; Stoica Alice; Radu Gabriel-Lucian; Radoi Antonio; Stoian Marius; Simionescu Octavian-Gabriel; Eremia Sandra A. V. | Chemosensors, 2024 | |
RezumatA nitrogen-doped nanocrystalline electrochemical graphite sensor for the sensitive determination of oleuropein (OL) from extra virgin olive oils (EVOOs) is presented. The sensor was developed by the deposition of nanocrystalline graphite (NCG) using plasma-enhanced chemical vapour deposition (PECVD) on silicon wafers. Scanning electron microscopy (SEM), energy dispersive X-ray analysis (EDX) and X-ray diffraction analysis (XRD) were used to characterise the microstructure and morphology of the developed materials. Cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS) and square wave voltammetry (SWV) were used to investigate the electrochemical properties of the material and the performance of the sensor. The developed sensor showed good analytical performance against OL over a concentration range of 5.00-500.00 mu M, with a good detection limit of 3.93 mu M and a good sensitivity of 0.057 mu A mu M-1. The reproducibility of the electrochemical sensor was excellent, with a relative standard deviation (RSD) of 8.56% for seven measurements. |
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article
Winemaking Technologies For The Production Of Cabernet Sauvignon And Feteasca Neagra Wines Enriched With Antioxidant Active Principles Due To The Addition Of Melatonin |
Eremia Sandra A. V.; Albu Camelia; Radu Gabriel-Lucian; Alecu Andreia; Stoica Alice G.; Brinduse Elena | Foods, 2024 | |
RezumatIn recent years, various studies have been carried out to increase the concentration of antioxidant active principles in red wines as a consequence of the effects of winemaking techniques on the polyphenols content. In this study, in order to obtain the most optimal wine in terms of content and efficiency of antioxidant activity, various winemaking technologies (punching-down and pumping-over maceration) were tried with diverse gradations (Feteasca Neagra and Cabernet Sauvignon wines) and the addition of different concentrations of melatonin in must. Suitable HPLC and spectrophotometric methods were used to follow the evolution of the antioxidant compounds from wines during aging (for 12 months). After comparing the acquired results, an increase was observed in the antioxidant compound concentrations, particularly in resveratrol (85%), peonidin-3-glucoside (100%) or cyanidin-3-glucoside (100%), and antioxidant activity (10-40%). The most enriched wine was obtained in the case of Feteasca Neagra by the addition of 0.5 mg of melatonin per 1 kg of must using the punch-down technology and, in the case of Cabernet Sauvignon, by the addition of 0.05 mg of melatonin per 1 kg of must using the pumping-over technique. This study can provide winemakers with an approach to enhance red wines with antioxidant compounds. |
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article
Integrating Demography And Distribution Modeling For The Iconic Leontopodium Alpinum Colm. In The Romanian Carpathians |
Maghiar Lacramioara M.; Stoica Ilie A.; Tanentzap Andrew J. | Ecology And Evolution, 2021 | |
RezumatBoth climate change and human exploitation are major threats to plant life in mountain environments. One species that may be particularly sensitive to both of these stressors is the iconic alpine flower edelweiss (Leontopodium alpinum Colm.). Its populations have declined across Europe due to over-collection for its highly prized flowers. Edelweiss is still subject to harvesting across the Romanian Carpathians, but no study has measured to what extent populations are vulnerable to anthropogenic change. Here, we estimated the effects of climate and human disturbance on the fitness of edelweiss. We combined demographic measurements with predictions of future range distribution under climate change to assess the viability of populations across Romania. We found that per capita and per-area seed number and seed mass were similarly promoted by both favorable environmental conditions, represented by rugged landscapes with relatively cold winters and wet summers, and reduced exposure to harvesting, represented by the distance of plants from hiking trails. Modeling these responses under future climate scenarios suggested a slight increase in per-area fitness. However, we found plant ranges contracted by between 14% and 35% by 2050, with plants pushed into high elevation sites. Synthesis. Both total seed number and seed mass are expected to decline across Romania despite individual edelweiss fitness benefiting from a warmer and wetter climate. More generally, our approach of coupling species distribution models with demographic measurements may better inform conservation strategies of ways to protect alpine life in a changing world. |
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