The project proposal "Functionalized 3D extracellular matrices based on mesoporous bioshells for hard tissue regeneration" aims to improve human well-being by providing a novel range of biomaterials. The objective of the project is to restore and improve hard tissue function through the use of functional bioactive extracellular matrices. These extracellular matrices will provide good mechanical properties in an environment suitable for tissue regeneration and repair. Cerium doped sodium-free mesoporous biostics (MBGs) will be used to fabricate the extracellular matrices using a combination of structure ordering agents and polymer foam replication. The BIOSCAFTIS project builds on the results obtained by our research group, which demonstrate that cerium doped MBGs have excellent bioactivity and biocompatibility. To enhance bone tissue growth and remodelling, the surface of the extracellular matrix will be functionalized with vitamin D3. The properties of the extracellular matrices (bioactivity, mechanical strength, antimicrobial activity and controlled drug release profile) will be assessed using appropriate characterisation techniques. The performance of extracellular matrix integration into native tissues will be investigated using in vitro experimental models mimicking the interaction with osteoblast cells. As a result of the research, the project aims to add value to the field of biomaterials by developing a new class of materials for medical applications.